Abstract | OBJECTIVE: METHODS: RESULTS: All patients reported increased exercise capacity with improvement in New York Heart Association functional class. The distance walked during the 6-min test increased by 74% (patient 1), 75% (patient 2) and 25% (patient 3) and oxyhaemoglobin saturations increased from 79%, 97% and 80% to 93%, 100% and 93%, respectively. There were no side effects and no fall in systemic blood pressure. Sildenafil plasma levels 1 h after a 0.5, 1.0 and 2 mg/kg dose of Sildenafil were 109+/-87, 150+/-62 and 368+/-200 ng/ml, respectively. They fell to 211+/-106 ng/ml 3 h after the 2.0 mg/kg dose. CONCLUSIONS: Medium term Sildenafil therapy improves oxyhaemoglobin saturations and exercise tolerance in children with pulmonary hypertension without any side effects. Mean plasma levels 1 h after doses of 0.5-2.0 mg/kg are similar to the maximum plasma concentrations reported in adults receiving doses within the therapeutic range. Sildenafil use in children appears to be safe and may be beneficial in the management of pulmonary arterial hypertension.
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Authors | Ageliki A Karatza, Andrew Bush, Alan G Magee |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 100
Issue 2
Pg. 267-73
(Apr 20 2005)
ISSN: 0167-5273 [Print] Netherlands |
PMID | 15823634
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phosphodiesterase Inhibitors
- Piperazines
- Purines
- Sulfones
- Sildenafil Citrate
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Topics |
- Administration, Oral
- Adolescent
- Child
- Chronic Disease
- Female
- Heart Defects, Congenital
(complications)
- Humans
- Hypertension, Pulmonary
(drug therapy, etiology)
- Male
- Phosphodiesterase Inhibitors
(adverse effects, pharmacokinetics, therapeutic use)
- Piperazines
(adverse effects, pharmacokinetics, therapeutic use)
- Purines
- Safety
- Sildenafil Citrate
- Sulfones
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