Implantation failures: success of assisted hatching with quarter-laser zona thinning.

Implantation failure after IVF is one of the factors associated with a reduced chance of pregnancy for some patients. Assisted hatching methodologies are designed to facilitate the embryo's escape from the zona pellucida, and this strategy has been suggested as a means of improving pregnancy rates in patients with previous implantation failure. The aim of this prospective and randomized study was to evaluate the efficacy of quarter-laser zona thinning assisted hatching (qLZT-AH) in improving the implantation of embryos in patients with previous implantation failure. A total of 150 patients with a history of previous implantation failure were treated with intracytoplasmic sperm injection, and allocated into two groups: group 1, only one previous implantation failure, and group 2, repeated implantation failures. The patients in each group were randomized at the time of embryo transfer into a control group (no qLZT-AH) or experimental group where qLZT-AH was performed. For patients with repeated implantation failures, the implantation rate in those who received laser-thinned embryos was significantly higher (P = 0.02) than in those whose embryos were not laser-thinned (10.9 and 2.6% respectively). However, this difference was not observed in patients who presented with only one previous implantation failure. The data demonstrate that qLZT-AH is an effective strategy for improving the implantation of embryos in patients with repeated implantation failures.
AuthorsC G Petersen, A L Mauri, R L Baruffi, J B A Oliveira, F C Massaro, K Elder, J G Franco Jr
JournalReproductive biomedicine online (Reprod Biomed Online) Vol. 10 Issue 2 Pg. 224-9 (Feb 2005) ISSN: 1472-6483 [Print] England
PMID15823228 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
  • Adult
  • Embryo Implantation (physiology)
  • Embryo Transfer
  • Female
  • Fertilization in Vitro (methods)
  • Humans
  • Infertility (therapy)
  • Laser Therapy
  • Pregnancy
  • Pregnancy Outcome
  • Prospective Studies
  • Sperm Injections, Intracytoplasmic
  • Zona Pellucida (radiation effects, ultrastructure)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: