A conserved HLA B13-restricted cytotoxic T lymphocyte epitope in Nef is a dominant epitope in HLA B13-positive HIV-1-infected patients.

Abstract

We report on the first HLA B13-restricted minimal cytotoxic T lymphocyte (CTL) epitope RQDILDLWI (RI9, amino acids 106-114 in HIV-1 Nef). In most patients the frequency of RI9-specific CTL exceeded the number of CTL against other epitopes, indicating that RI9 is a dominant epitope in HLA B13-positive patients. Targeting this conserved Nef epitope may be an important factor for the published association of HLA B13 with a favourable course of HIV-1 infection.

• Authors: Ellen G Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M Müller, Bernd M Spriewald, Thomas Harrer
• Journal: AIDS (London, England) (AIDS) Vol. 19 Issue 7 Pg. 734-5 (Apr 29 2005) ISSN: 0269-9370 [Print] England
• PMID: 15821402 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epitopes, T-Lymphocyte
• Gene Products, nef
• HLA-B Antigens
• HLA-B13 Antigen
• Immunodominant Epitopes
• nef Gene Products, Human Immunodeficiency Virus

Topics

• Amino Acid Motifs
• Consensus Sequence
• Cytotoxicity, Immunologic
• Epitope Mapping
• Epitopes, T-Lymphocyte
• Gene Products, nef
• HIV Infections (immunology, mortality)
• HIV-1 (immunology, isolation & purification)
• HLA-B Antigens
• HLA-B13 Antigen
• Humans
• Immunodominant Epitopes
• Survival Rate
• T-Lymphocytes, Cytotoxic (immunology)
• nef Gene Products, Human Immunodeficiency Virus