Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.

Abstract

OBJECTIVES:

Serum xylosyltransferase I (XT-I) is a marker for the determination of tissue remodeling in systemic sclerosis. Here, we investigated whether renal insufficiency affects XT-I levels in blood.

METHODS:

We measured serum XT-I activity in 236 patients with different serum creatinine levels.

RESULTS:

XT-I activities in cohorts with increased creatinine levels were not significantly altered compared to controls.

CONCLUSIONS:

Serum XT-I activity is applicable as a fibrosis marker independent from renal function.

• Authors: Manuela Schöttler, Sandra Müller, Sylvia Schön, Christian Prante, Joachim Kuhn, Knut Kleesiek, Christian Götting
• Journal: Clinical biochemistry (Clin Biochem) Vol. 38 Issue 5 Pg. 486-8 (May 2005) ISSN: 0009-9120 [Print] United States
• PMID: 15820781 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Creatinine
• Pentosyltransferases
• UDP xylose-protein xylosyltransferase

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Creatinine (blood)
• Female
• Humans
• Liver Cirrhosis (blood, complications)
• Male
• Middle Aged
• Pentosyltransferases (blood)
• Renal Insufficiency (blood, complications)