Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms.

Abstract

Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n = 335) from north India. Tardive dyskinesia was diagnosed in approximately 29% (96/335) of these patients. No significant association of either of the two SNPs with TD (CYP3A4*1B chi2 = 0. 308, df = 1, p = 0.579; CYP2D6*4 chi2 = 0.006, df = 1, p = 0.935) was observed. However a trend towards increased severity of TD in patients heterozygous for the CYP2D6*4 mutation was observed.

• Authors: Arun K Tiwari, Smita N Deshpande, A R Rao, Triptish Bhatia, Bernard Lerer, Vishwajit L Nimgaonkar, B K Thelma
• Journal: Schizophrenia research (Schizophr Res) Vol. 75 Issue 1 Pg. 21-6 (Jun 01 2005) ISSN: 0920-9964 [Print] Netherlands
• PMID: 15820320 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Cytochrome P-450 Enzyme System
• CYP3A protein, human
• Cytochrome P-450 CYP2D6
• Cytochrome P-450 CYP3A
• CYP3A4 protein, human

Topics

• Analysis of Variance
• Antipsychotic Agents (adverse effects)
• Asian People (genetics)
• Case-Control Studies
• Cross-Sectional Studies
• Cytochrome P-450 CYP2D6 (genetics)
• Cytochrome P-450 CYP3A
• Cytochrome P-450 Enzyme System (genetics)
• Dyskinesia, Drug-Induced (ethnology, genetics)
• Genetic Predisposition to Disease (ethnology, genetics)
• Humans
• India (epidemiology)
• Pharmacogenetics
• Polymorphism, Single Nucleotide
• Retrospective Studies
• Schizophrenia (drug therapy)