Abstract | BACKGROUND: Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth. METHODS: The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single-dose irradiation and 5x/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis. RESULTS: CONCLUSIONS: This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure.
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Authors | Yuquan Shi, Caroline S Lee, Junmin Wu, Cameron J Koch, Stephen R Thom, Amit Maity, Eric J Bernhard |
Journal | Head & neck
(Head Neck)
Vol. 27
Issue 5
Pg. 362-9
(May 2005)
ISSN: 1043-3074 [Print] United States |
PMID | 15818558
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Copyright | 2005 Wiley Periodicals, Inc. |
Chemical References |
- Vascular Endothelial Growth Factor A
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Topics |
- Animals
- Carcinoma, Squamous Cell
(blood supply, metabolism, pathology)
- Cell Hypoxia
- Dose-Response Relationship, Radiation
- Head and Neck Neoplasms
(blood supply, metabolism, pathology)
- Hyperbaric Oxygenation
- Immunohistochemistry
- Male
- Mice
- Mice, Nude
- Neoplasms, Experimental
- Neovascularization, Pathologic
- Transplantation, Heterologous
- Vascular Endothelial Growth Factor A
(metabolism)
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