Cefditoren pivoxil (
Spectracef, Meiact) is a third-generation oral
cephalosporin with a broad spectrum of activity against pathogens, including both Gram-positive and -negative bacteria, and is stable to hydrolysis by many common
beta-lactamases.
Cefditoren pivoxil is approved for use in the treatment of acute exacerbations of
chronic bronchitis (AECB), mild-to-moderate community-acquired
pneumonia (CAP), acute
maxillary sinusitis, acute
pharyngitis/
tonsillitis, and uncomplicated skin and skin structure
infections (indications may differ between countries). In clinical trials in adults and adolescents,
cefditoren pivoxil demonstrated good clinical and bacteriological efficacy in AECB, CAP, acute
maxillary sinusitis, acute
pharyngitis/
tonsillitis, and uncomplicated skin and skin structure
infections, and was generally well tolerated. Thus,
cefditoren pivoxil is a good option for the treatment of adult and adolescent patients with specific respiratory tract or skin
infections, particularly if there is concern about Streptococcus pneumoniae with decreased susceptibility to
penicillin, or
beta-lactamase-mediated resistance among the common community-acquired pathogens.