| Abstract | Some recently introduced vaccines that have excellent efficacy records have been developed without a clear understanding of their mechanism of protection. In fact, successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases. |
| Authors | Paul-Henri Lambert, Margaret Liu, Claire-Anne Siegrist
(Affiliation: Centre of Vaccinology, Department of Immunology-Pathology, University of Geneva-CMU, 1 rue Michel-Servet, 1211 Geneva, Switzerland. paul.lambert at medecine.unige.ch)
|
| Journal | Nature medicine
(Nat Med)
Vol. 11
Issue 4 Suppl
Pg. S54-62
(Apr 2005)
ISSN: 1078-8956 United States |
| PMID | 15812491
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antibodies
- Antigens
- Vaccines
|
| Topics |
- Aged
- Antibodies
(blood)
- Antibody Affinity
- Antigenic Variation
- Antigens
(immunology)
- Humans
- Immunity, Cellular
- Immunologic Memory
- Infant
- Vaccines
(immunology)
|
