Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.

Abstract

Uteroglobin-related protein 2 (UGRP2) is thought to play a role in inflammation and/or epithelial cell differentiation in the lung. Induction of Ugrp2 mRNA expression by epidermal growth factor (EGF) and transforming growth factor alpha was examined using mouse transformed lung Clara cell-derived mtCC cells. The EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways.

• Authors: Atsushi Yamada, Shioko Kimura
• Journal: FEBS letters (FEBS Lett) Vol. 579 Issue 10 Pg. 2221-5 (Apr 11 2005) ISSN: 0014-5793 [Print] England
• PMID: 15811345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Primers
• Proteins
• RNA, Messenger
• Transforming Growth Factor alpha
• UGRP2 protein, mouse
• Epidermal Growth Factor

Topics

• Animals
• Base Sequence
• Blotting, Northern
• Blotting, Western
• DNA Primers
• Epidermal Growth Factor (physiology)
• Gene Expression Regulation (physiology)
• Lung (cytology, metabolism)
• MAP Kinase Signaling System
• Mice
• Proteins (genetics)
• RNA, Messenger (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Transforming Growth Factor alpha (physiology)