[Anti-tumor effects of ampelopsin on human lung cancer GLC-82 implanted in nude mice].

Abstract

OBJECTIVE:

To investigate the effects of ampelopsin on the growth of human lung cancer cell line GLC-82 in nude mice.

METHODS:

GLC-82 cells were inoculated into the armpit of nude mice to establish lung cancer model. Then the BALB/C nude mice 6 with xenograft tumor were randomized into 6 groups. Ampelopsin was administered at 3 dosages by intraperitoneal injection daily. The anti-tumor effect of ampelopsin was evaluated on tumor volume, relative tumor volume, tumor weight, relative tumor proliferative rale, and tumor growth curve.

RESULTS:

At the 250 mg/kg dose of ampelopsin, the growth inhibition of the transplant tumor was 35.5% (P < 0.01) and 37.1% (P < 0.01), and the relative tumor proliferative rate was 55.24% (P < 0.01) and 57.71% (P < 0.05), respectively in two independent experiments by compared with the normal saline control.

CONCLUSION:

Ampelopsin appears to be a potent anti-tumor agent that was firstly discovered in the transplant human lung cancer cell line GLC-82 in nude mice in vivo.

• Authors: Sa Zeng, Deyu Liu, Yanli Ye, Liangui Wang, Wei Wang
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 27 Issue 11 Pg. 842-5 (Nov 2004) ISSN: 1001-4454 [Print] China
• PMID: 15810594 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Flavonoids
• ampelopsin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Female
• Flavonoids (pharmacology)
• Humans
• Lung Neoplasms (drug therapy, pathology)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Neoplasm Transplantation
• Plants, Medicinal (chemistry)
• Time Factors