Abstract |
The recommended dose of Vitamin E in human pregnancy is 22-30 mg/day. High doses of Vitamin E (>or=400 IU/day) have been shown to attenuate or even prevent the damaging effect of ethanol and diabetes on the fetus in experimental animal models. The Motherisk program prospectively enrolled, and followed-up on, 82 pregnant women exposed to high doses (>or=400 IU/day) of Vitamin E during the first trimester of pregnancy. Pregnancy outcome was compared to a matched control group. The study group (n=82) was exposed to Vitamin E at doses ranging from 400-1200 IU/day. There was one pregnancy with major malformation ( omphalocele) in study group. There was an apparent decrease in mean birth weight (3173+/-467 g) in Vitamin E group as compare to control (3417+/-565 g; P=0.0015); however, there were no significant differences in rates of live births, preterm deliveries, miscarriages and stillbirths. Therefore, it is concluded that consumption of high doses of Vitamin E during the first trimester of pregnancy does not appear to be associated with an increased risk for major malformations, but may be associated with decrease in birth weight.
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Authors | Rada Boskovic, Liubov Gargaun, Dana Oren, Josephine Djulus, Gideon Koren |
Journal | Reproductive toxicology (Elmsford, N.Y.)
(Reprod Toxicol)
2005 May-Jun
Vol. 20
Issue 1
Pg. 85-8
ISSN: 0890-6238 [Print] United States |
PMID | 15808790
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Antioxidants
(adverse effects)
- Birth Weight
(drug effects)
- Canada
(epidemiology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Infant, Newborn
- Male
- Maternal Exposure
(adverse effects)
- Pregnancy
- Pregnancy Outcome
(epidemiology)
- Pregnancy Trimester, First
- Prospective Studies
- Vitamin E
(administration & dosage)
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