[Immunogenetic HLA markers of chronic viral hepatitis].

Abstract

AIM:

To study possible immunogenetic HLA markers of chronic viral hepatitides.

MATERIAL AND METHODS:

Using the reaction of complement-dependent cytotoxicity by Terasaki, we analysed distribution of leukocytic HLA antigens (loci A, B and C) in 179 patients with chronic viral hepatitides B, C and D in Russians and Kazakhs living in the Astrakhan Region.

RESULTS:

In the Russian population we discovered a significant positive association of CVHB with HLA-B18, HLA-B35, HLA-B40, HLA-Cw3 antigens, and negative one--with HLA-A2. In Kazakhs with CVHB there was a positive association with HLA-A3, HLA-B18 and negative one--with HLA-A11. Alleles HLA-A10, HLA-B35, HLA-B40 and HLA-Cw3 mark CVHC in Russians. HLA-Cw4 specificity acts as protector in development of chronic HCV-infection. A correlation was found between carriage of some specificities and haplotypes of HLA and activity of chronic HBV and HCV infection. A high risk of chronic delta infection in Russians is associated with HLA-B8 and HLA-B35, in Kazakhs--with HLA-B35 and HLA-D40. There are significant associations between CVHB, CVHC, chronic delta infection and some HLA haplotypes.

CONCLUSION:

A universal role of HLA-B35 specificity in development of CVH irrespective of hepatotropic virus and patients' nationality is shown.

• Authors: E A Popov, B N Levitan, L P Alekseev, O A Pronina, S V Suchkov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 77 Issue 2 Pg. 54-9 ( 2005) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 15807454 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA Antigens
• HLA-C Antigens
• HLA-C*04 antigen

Topics

• Chronic Disease
• HLA Antigens (immunology)
• HLA-C Antigens (immunology)
• Hepatitis A (ethnology, immunology)
• Hepatitis B (ethnology, immunology)
• Hepatitis C (ethnology, immunology)
• Hepatitis D (ethnology, immunology)
• Hepatitis, Viral, Human (ethnology, immunology)
• Humans
• Kazakhstan
• Russia