Uterine epithelioid endometrial stromal sarcoma presenting as a "cervical polyp".

Abstract

Although appearance of conventional uterine endometrial stromal sarcoma is easily recognized on histology, it may uncommonly assume unusual appearances such as uterine tumor resembling ovarian sex-cord tumor, thereby hindering its diagnosis. Recently, its manifestation as an epithelioid neoplasm was described. In this report, we detail yet another instance where this tumor adopted an epithelioid morphology, presenting itself as a polyp extruding from the cervical os in a 41-year-old Chinese woman. Both the polypectomy and subsequent hysterectomy specimens revealed a predominant proliferation of CD10-negative, caldesmon-negative, and CD117-positive epithelioid cells set within a stroma containing vascular proliferation resembling endometrial stromal tumor. Areas of typical low-grade endometrial stromal sarcoma containing spindle cells that were focally positive for CD10 and negative for CD117 were present in close association with the epithelioid areas. The differential diagnoses and possible implication of CD117 positivity are discussed.

• Authors: Seng Geok Nicholas Goh, Khoon Leong Chuah, Sung Hock Chew, Puay Hoon Tan
• Journal: Annals of diagnostic pathology (Ann Diagn Pathol) Vol. 9 Issue 2 Pg. 101-5 (Apr 2005) ISSN: 1092-9134 [Print] United States
• PMID: 15806518 (Publication Type: Case Reports, Journal Article)

Chemical References

• Proto-Oncogene Proteins c-kit
• Neprilysin

Topics

• Adult
• Diagnosis, Differential
• Endometrial Neoplasms (diagnosis, metabolism, pathology)
• Female
• Humans
• Neprilysin (metabolism)
• Polyps (diagnosis)
• Proto-Oncogene Proteins c-kit (metabolism)
• Sarcoma, Endometrial Stromal (diagnosis, metabolism, pathology)
• Uterine Cervical Neoplasms (diagnosis)