In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone in a solid human carcinoma xenograft model.

Abstract

Previously we have shown that 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42+/-0.11 g and 0.59+/-0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60+/-0.80% of the total in mice injected with 150 mg/kg DMC). To our knowledge, this is the first time that chalcone compounds have been applied to a human tumor xenograft model.

• Authors: Chun-Lin Ye, Jian-Wen Liu, Dong-Zhi Wei, Yan-Hua Lu, Feng Qian
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 56 Issue 1 Pg. 70-4 (Jul 2005) ISSN: 0344-5704 [Print] Germany
• PMID: 15806415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone
• Chalcones
• Plant Extracts
• Chalcone

Topics

• Animals
• Carcinoma (pathology)
• Chalcone (analogs & derivatives, pharmacology)
• Chalcones
• Disease Models, Animal
• Drug Screening Assays, Antitumor
• Liver Neoplasms (pathology)
• Mice
• Myrtaceae (chemistry)
• Plant Extracts (pharmacology)
• Transplantation, Heterologous