Abstract |
To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) of the central nervous system (CNS), we analyzed 10 cases of IMTs-CNS (8 cranial, 1 spinal, and 1 orbital). Our series of IMTs of the CNS showed a male predominance (male:female = 6:4) and a wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, they showed two patterns: isolated mass forming (n = 6) and an en plaque-like pattern (n = 4). Histopathologically, plasma cell granuloma (PCG)-like (n = 5) or fibrohistiocytic (FHC) variant (n = 5) was present. No correlation was found between the radiologic and histopathologic patterns. Spindle-shaped mesenchymal cells of IMTs expressed smooth muscle actin (SMA) in all cases. ALK expression was not found in our IMTs of the CNS. Late recurrence was found in 2 cases in different sites (20%). Pathologically, IMT-CNS could be subclassified into PCG-like and FHC. Immunostaining for SMA was found to helpfully discriminate myofibroblastic cells and to make a differential diagnosis. Although our cases did not show ALK immunoreactivity, some IMTs-CNS can recur, which suggests the neoplastic potential of these tumors. The rearrangement of the ALK gene in IMTs-CNS should be verified by an examination of more cases.
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Authors | Yoon Kyung Jeon, Kee-Hyun Chang, Yeon-Lim Suh, Hee Won Jung, Sung-Hye Park |
Journal | Journal of neuropathology and experimental neurology
(J Neuropathol Exp Neurol)
Vol. 64
Issue 3
Pg. 254-9
(Mar 2005)
ISSN: 0022-3069 [Print] England |
PMID | 15804057
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Actins
(metabolism)
- Adult
- Aged
- Central Nervous System Neoplasms
(metabolism, pathology)
- Female
- Granuloma, Plasma Cell
(metabolism, pathology, physiopathology)
- Humans
- Immunohistochemistry
(methods)
- Inflammation
(etiology, pathology)
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Neoplasms, Muscle Tissue
(complications, metabolism, pathology)
- Sex Factors
- Staining and Labeling
(methods)
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