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[The effect of combined mitoxantrone and methylprednisolone therapy in primary and secondary progressive multiple sclerosis. An applied study in 65 patients].

Abstract
Mitoxantrone (mitox) has been shown to be effective for secondary progressive (SP) and relapsing-remitting multiple sclerosis (MS). The aim of this open trial was to evaluate the effects of combined mitox and methylprednisolone (MP) therapy on patients with primary progressive (PP)-MS or with SP-MS. We present here the results of an interim analysis done after the study had lasted 5 years. Sixty-five patients (20 with PP-MS and 45 with SP-MS) have been included so far. The treatment involved ten cycles of combined mitox and MP. The intervals between the individual cycles were systematically prolonged from 3 months initially to 12 months, so the complete treatment took a total of 57 months. Conclusion This interim analysis indicates that mitox combined with MP beneficially reduces the progression of disability in patients with PP-MS and SP-MS. Therefore, this therapy regimen can also be considered a feasible option for PP-MS.
AuthorsV C Zingler, M Strupp, K Jahn, A Gross, R Hohlfeld, T Brandt
JournalDer Nervenarzt (Nervenarzt) Vol. 76 Issue 6 Pg. 740-7 (Jun 2005) ISSN: 0028-2804 [Print] Germany
Vernacular TitleKombinierte Mitoxantron-/Methylprednisolon-Behandlung bei primär und sekundär chronisch progredienter Multipler Sklerose. Eine Anwendungsbeobachtung bei 65 Patienten.
PMID15803287 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Analgesics
  • Drug Combinations
  • Mitoxantrone
  • Methylprednisolone
Topics
  • Adult
  • Aged
  • Analgesics (administration & dosage)
  • Disease Progression
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Methylprednisolone (administration & dosage)
  • Middle Aged
  • Mitoxantrone (administration & dosage)
  • Multiple Sclerosis, Chronic Progressive (drug therapy, prevention & control)
  • Prognosis
  • Recovery of Function (drug effects)
  • Secondary Prevention
  • Treatment Outcome

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