Abstract |
Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti-TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.
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Authors | Hampar Akkaya, Oner Dogan, Mehmet Agan, Guncag Dincol |
Journal | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
(APMIS)
Vol. 113
Issue 3
Pg. 162-6
(Mar 2005)
ISSN: 0903-4641 [Print] Denmark |
PMID | 15799758
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, CD20
- CD5 Antigens
- Isoenzymes
- Acid Phosphatase
- Tartrate-Resistant Acid Phosphatase
|
Topics |
- Acid Phosphatase
(analysis, immunology)
- Antibodies, Monoclonal
(immunology)
- Antigens, CD20
(analysis, immunology)
- Bone Marrow Cells
(immunology)
- CD5 Antigens
(analysis, immunology)
- Humans
- Immunohistochemistry
- Isoenzymes
(analysis, immunology)
- Leukemia, Hairy Cell
(diagnosis, enzymology)
- Liver
(immunology)
- Osteoclasts
(chemistry)
- Spleen
(immunology)
- Tartrate-Resistant Acid Phosphatase
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