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The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia.

Abstract
Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti-TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.
AuthorsHampar Akkaya, Oner Dogan, Mehmet Agan, Guncag Dincol
JournalAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica (APMIS) Vol. 113 Issue 3 Pg. 162-6 (Mar 2005) ISSN: 0903-4641 [Print] Denmark
PMID15799758 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, CD20
  • CD5 Antigens
  • Isoenzymes
  • Acid Phosphatase
  • Tartrate-Resistant Acid Phosphatase
Topics
  • Acid Phosphatase (analysis, immunology)
  • Antibodies, Monoclonal (immunology)
  • Antigens, CD20 (analysis, immunology)
  • Bone Marrow Cells (immunology)
  • CD5 Antigens (analysis, immunology)
  • Humans
  • Immunohistochemistry
  • Isoenzymes (analysis, immunology)
  • Leukemia, Hairy Cell (diagnosis, enzymology)
  • Liver (immunology)
  • Osteoclasts (chemistry)
  • Spleen (immunology)
  • Tartrate-Resistant Acid Phosphatase

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