| Abstract | PURPOSE: To evaluate serum 25-hydroxyvitamin D [25(OH)D] concentrations and factors related to vitamin D inadequacy in postmenopausal North American women receiving therapy to treat or prevent osteoporosis. METHODS: Serum 25(OH)D and PTH were obtained in 1536 community-dwelling women between November 2003 and March 2004. Multivariate logistic regression was used to assess risk factors for suboptimal (<30 ng/ml) 25(OH)D. RESULTS: Ninety-two percent of study subjects were Caucasian, with a mean age of 71 yr. Thirty-five percent resided at or above latitude 42 degrees north, and 24% resided less than 35 degrees north. Mean (sd) serum 25(OH)D was 30.4 (13.2) ng/ml: serum 25(OH)D was less than 20 ng/ml in 18%; less than 25 ng/ml in 36%; and less than 30 ng/ml in 52%. Prevalence of suboptimal 25(OH)D was significantly higher in subjects who took less than 400 vs. 400 IU/d or more vitamin D. There was a significant negative correlation between serum PTH concentrations and 25(OH)D. Risk factors related to vitamin D inadequacy included age, race, body mass index, medications known to affect vitamin D metabolism, vitamin D supplementation, exercise, education, and physician counseling regarding vitamin D. CONCLUSIONS: More than half of North American women receiving therapy to treat or prevent osteoporosis have vitamin D inadequacy, underscoring the need for improved physician and public education regarding optimization of vitamin D status in this population. |
| Authors | Michael F Holick, Ethel S Siris, Neil Binkley, Mary K Beard, Aliya Khan, Jennifer T Katzer, Richard A Petruschke, Erluo Chen, Anne E de Papp
(Affiliation: Boston University School of Medicine, 715 Albany Street, M1013, Boston, Massachusetts 02118, USA. mfholick at bu.edu)
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| Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 90
Issue 6
Pg. 3215-24
(Jun 2005)
ISSN: 0021-972X United States |
| PMID | 15797954
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Parathyroid Hormone
- Calcifediol
|
| Topics |
- Accidental Falls
(statistics & numerical data)
- Activities of Daily Living
- Calcifediol
(blood, deficiency)
- Demography
- Educational Status
- Female
- Fractures, Bone
(epidemiology)
- Health Status
- Humans
- Income
- Middle Aged
- North America
(epidemiology)
- Osteoporosis, Postmenopausal
(drug therapy, prevention & control)
- Parathyroid Hormone
(blood)
- Prevalence
- Regression Analysis
- Risk Factors
- Vitamin D Deficiency
(epidemiology)
|
