Abstract | BACKGROUND: METHODS: Hypertensive SHR and normotensive Wistar Kyoto (WKY) rats were used. Clearance experiments were performed and the effect of 1 mg/kg body weight (given intravenously) synthesized NPS R-568 (NPS) on MAP in the presence or absence of thyroparathyroidectomy (TPTX) was monitored. RESULTS: The success phPTX and TPTX were proven by a significant decrease in plasma Ca(2+) concentration and a decrease in urinary fractional phosphate excretion (FE Pi). The administration of NPS significantly decreased blood pressure in SHR versus SHR/control: Delta(0-50 min of experiment) MAP -16.5 +/- 2.5 mm Hg v -3.2 +/- 1.5 mm Hg (P < .002). The TPTX decreased blood pressure in SHR versus SHR/control and was not different versus SHR/TPTX/NPS (DeltaMAP: -10.2 +/- 1.6 mm Hg v -3.2 +/- 1.5 mm Hg (P < .01) and v -8.3 +/- 2.2 mm Hg (P = not significant). In normotensive WKY rats application of NPS did not reach significance in DeltaMAP: -6.7 +/- 1.8 mm Hg v -2.6 +/- 2.8 mm Hg (P = not significant) in WKY/control. The TPTX lowered blood pressure in WKY versus WKY/control and remained unchanged versus WKY/TPTX/NPS (DeltaMAP: -11.3 +/- 1.7 mm Hg v -2.6 +/- 2.8 mm Hg (P < .04) and v -11.4 +/- 2.6 mm Hg (P = not significant). CONCLUSIONS: We conclude that phPTX with NPS R-568 is responsible for a decrease of MAP in SHR.
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Authors | Apolonia Rybczyńska, Konrad Boblewski, Artur Lehmann, Czeslawa Orlewska, Henryk Foks, Krystyna Drewnowska, Anzelm Hoppe |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 18
Issue 3
Pg. 364-71
(Mar 2005)
ISSN: 0895-7061 [Print] United States |
PMID | 15797655
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aniline Compounds
- N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine
- Phenethylamines
- Phosphates
- Propylamines
- Calcium
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Topics |
- Aniline Compounds
(pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Calcium
(agonists, metabolism)
- Hyperparathyroidism
(surgery)
- Hypertension
(drug therapy)
- Hypotension
(chemically induced)
- Male
- Parathyroid Glands
(physiology)
- Parathyroidectomy
- Phenethylamines
- Phosphates
(metabolism)
- Propylamines
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
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