Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.

Abstract	We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.
Authors	Milagros Corrales, Rubén Cardozo, María Asunción Segura, Julio A Urbina, Miguel Angel Basombrío
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 49 Issue 4 Pg. 1556-60 (Apr 2005) ISSN: 0066-4804 [Print] United States
PMID	15793138 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Nitroimidazoles Triazoles Trypanocidal Agents TAK 187 benzonidazole Ergosterol
Topics	Acute Disease Animals Chagas Cardiomyopathy (prevention & control) Chagas Disease (drug therapy, parasitology) Disease Models, Animal Ergosterol (antagonists & inhibitors, biosynthesis) Male Mice Nitroimidazoles (therapeutic use) Triazoles (therapeutic use) Trypanocidal Agents (therapeutic use) Trypanosoma cruzi (drug effects, pathogenicity)

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