Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS:
Legumain expression was increased in primary tumors compared with distant or adjacent normal mucosa (P < 0.05), but there was no significant change between primary tumors and metastases (P > 0.05). Legumain expression was positively related to poorer differentiation/ mucinous carcinoma (P = 0.04), higher degree of necrosis (P = 0.03) and apoptosis (P < 0.0001), positive proliferating cell nuclear antigen (P < 0.0001) and p53 expression (P = 0.049), and had a positive tendency towards stromelysin 3 (P = 0.058) and PINCH positivity (P = 0.05). The patients with tumors that showed both weak and lower percentage of the legumain expression, either in tumor (P = 0.01) or in stroma (P = 0.04), had a better prognosis. CONCLUSIONS:
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Authors | Raghavendra Vasudeva Murthy, Gunnar Arbman, Jingfang Gao, G David Roodman, Xiao-Feng Sun |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 11
Issue 6
Pg. 2293-9
(Mar 15 2005)
ISSN: 1078-0432 [Print] United States |
PMID | 15788679
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cysteine Endopeptidases
- asparaginylendopeptidase
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Topics |
- Adenocarcinoma
(enzymology, secondary)
- Adenocarcinoma, Mucinous
(enzymology, pathology)
- Adult
- Aged
- Aged, 80 and over
- Cell Differentiation
- Colon
(enzymology)
- Colorectal Neoplasms
(enzymology, pathology)
- Cysteine Endopeptidases
(metabolism)
- Female
- Humans
- Immunoenzyme Techniques
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
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