Descending thoracic aortic aneurysm repair with the aid of partial cardiopulmonary bypass: heparin-coated circuits versus nonheparin-coated circuits.

Abstract

BACKGROUND:

We have performed descending thoracic aortic aneurysm repairs with partial cardiopulmonary bypass, including heparin-coated circuits. The aim of this study was to evaluate (i) the impact of partial cardiopulmonary bypass on distal organ function and surgical outcomes; and (ii) the effectiveness of using heparin-coated circuits for preventing bleeding complications.

METHODS:

From July 1980 to June 2004, 309 patients underwent descending thoracic aortic aneurysm repairs using partial cardiopulmonary bypass. Their mean age was 61 years (range 19-81 years). One hundred of the 309 patients underwent repair of descending thoracic aortic aneurysm with heparin-coated circuits. Blood data for renal and hepatic function were collected on the day before the operation and postoperative days.

RESULTS:

The in-hospital mortality was 15%. Distal organ dysfunction included spinal cord dysfunction in 2 patients (0.7%) and renal failure necessitating hemodialysis in 15 patients (5%, 15/297: excluded 12 dialysis patients). Multivariate analyses showed that preoperative hemodialysis and emergency operation were risk factors for operative mortality and that emergency operation was a risk factor for requiring hemodialysis. Renal and hepatic function normalized by 2 weeks after surgery. There were no significant differences between the heparin-coated group and nonheparin-coated group in amounts of packed red cells, fresh frozen plasma, and platelets transfused during the procedures.

CONCLUSIONS:

Our data showed that partial cardiopulmonary bypass is a safe and effective method for distal perfusion. Using this technique, descending thoracic aortic aneurysm repair can be performed with acceptable mortality and morbidity. However, the superiority of heparin-coated circuits over nonheparin-coated ones was not proved.

• Authors: Kiyofumi Morishita, Nobuyoshi Kawaharada, Johji Fukada, Yoshikazu Hachiro, Yoshihiko Kurimoto, Yasuaki Fujisawa, Tatsuya Saito, Tomio Abe
• Journal: Artificial organs (Artif Organs) Vol. 29 Issue 4 Pg. 300-5 (Apr 2005) ISSN: 0160-564X [Print] United States
• PMID: 15787624 (Publication Type: Journal Article)

Chemical References

• Anticoagulants
• Heparin
• Creatinine
• Alanine Transaminase

Topics

• Adult
• Aged
• Aged, 80 and over
• Alanine Transaminase (blood)
• Anticoagulants (administration & dosage)
• Aortic Aneurysm, Thoracic (blood, surgery)
• Cardiopulmonary Bypass (methods)
• Creatinine (blood)
• Female
• Heparin (administration & dosage)
• Humans
• Kidney (physiopathology)
• Liver (physiopathology)
• Male
• Middle Aged
• Perfusion (instrumentation)
• Postoperative Hemorrhage (prevention & control)
• Treatment Outcome