Abstract | AIM: METHODS: We prospectively studied 115 consecutive patients with H pylori-infected active peptic ulcers. H pylori infection was confirmed if any two of H pylori DNA, histology, and rapid urease test were positive. Patients were assigned to either an open-labeled 3-d course of oral amoxicillin 1 000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 20 mg b.i.d., or 7-d course of oral amoxicillin 1 000 mg b.i.d., clarithromycin 500 mg b.i.d., and rabeprazole 20 mg b.i.d. Subsequently, all patients received oral rabeprazole 20 mg once daily until the 8th wk. Three months after therapy, all patients were followed-up endoscopically for the peptic ulcer, H pylori DNA, histology, and rapid urease test. One year after therapy, H pylori infection was tested using the 13C-urea breath test. RESULTS: The ulcer healing rates 3 mo after therapy were 81.0% vs 75.4% for the 3-d and 7-d groups [intention-to-treat (ITT) analysis, P = 0.47] respectively, and 90.4% vs 89.6% for the 3-d and 7-d groups [per-protocol (PP) analysis, P = 0.89] respectively. The eradication rates 3 mo after therapy were 75.9% vs 73.7% for the 3-d and 7-d groups (ITT, P = 0.79) respectively, and 84.6% vs 87.5% for the 3-d and 7-d groups (PP, P = 0.68) respectively. One year after therapy, seventy-five patients returned to receive the 13C-urea breath test, and the eradication rates were 78.4% vs 81.6% in 3-d and 7-d groups (PP, P = 0.73) respectively. CONCLUSION:
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Authors | Hwang-Huei Wang, Jen-Wei Chou, Kuan-Fu Liao, Zong-Yi Lin, Hsueh-Chou Lai, Chang-Hu Hsu, Chih-Bin Chen |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 11
Issue 11
Pg. 1680-4
(Mar 21 2005)
ISSN: 1007-9327 [Print] United States |
PMID | 15786549
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Benzimidazoles
- Carbon Isotopes
- Rabeprazole
- Amoxicillin
- Urea
- Clarithromycin
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Amoxicillin
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Ulcer Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Breath Tests
- Carbon Isotopes
- Clarithromycin
(therapeutic use)
- Female
- Follow-Up Studies
- Helicobacter Infections
(diagnosis, drug therapy)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives, therapeutic use)
- Prospective Studies
- Rabeprazole
- Treatment Outcome
- Urea
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