Ramoplanin: a lipoglycodepsipeptide antibiotic.

Abstract

OBJECTIVE:

To review the pharmacology, antimicrobial activity, pharmacokinetics, clinical applications, and safety of ramoplanin, a lipoglycodepsipeptide antibiotic.

DATA SOURCES:

Information was obtained from MEDLINE and BIOSIS databases (1984-August 2004) and Oscient Pharmaceuticals using the key words ramoplanin, A 16686, A 16686A, and MDL 62198.

STUDY SELECTION AND DATA EXTRACTION:

Available English-based articles and abstracts were reviewed, along with information from Oscient Pharmaceuticals.

DATA SYNTHESIS:

Ramoplanin exerts its bactericidal activity against gram-positive aerobic and anaerobic bacteria by blocking peptidoglycan synthesis via lipid II. In vitro susceptibility reports have demonstrated efficacy against antibiotic-resistant gram-positive pathogens. Cross-resistance has not been documented with vancomyin and other glycopeptides. Clinical trials are investigating ramoplanin's oral administration for treatment of Clostridium difficile-associated diarrhea. Previous clinical trials had evaluated the suppression of colonization of vancomycin-resistant Enterococcus with ramoplanin. Adverse effects are minimal, and drug-drug interactions have not been documented.

CONCLUSIONS:

The completion of clinical trials will determine whether ramoplanin has a promising role as a treatment option for diarrhea due to C. difficile.

• Authors: Debra K Farver, Dennis D Hedge, Steven C Lee
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 39 Issue 5 Pg. 863-8 (May 2005) ISSN: 1060-0280 [Print] United States
• PMID: 15784805 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Depsipeptides
• ramoplanin

Topics

• Adult
• Anti-Bacterial Agents (adverse effects, pharmacokinetics, therapeutic use)
• Clinical Trials as Topic
• Clostridioides difficile (drug effects, pathogenicity)
• Depsipeptides (adverse effects, pharmacokinetics, therapeutic use)
• Diarrhea (drug therapy)
• Humans
• Microbial Sensitivity Tests