Abstract | BACKGROUND: METHODS: One hundred and sixty subjects with type 2 diabetes and diabetic retinopathy were compared with 101 diabetic subjects without diabetic retinopathy. Chi-square test was used to compare discrete variables, and continuous clinical data were compared by unpaired students t - test. RESULTS: CONCLUSIONS: The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
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Authors | Mojca Globocnik Petrovic, Tanja Kunej, Borut Peterlin, Peter Dovc, Daniel Petrovic |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
2005 Sep-Oct
Vol. 21
Issue 5
Pg. 470-4
ISSN: 1520-7552 [Print] England |
PMID | 15782399
(Publication Type: Journal Article)
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Copyright | Copyright 2005 John Wiley & Sons, Ltd. |
Chemical References |
- PPAR gamma
- Transcription Factors
- peroxisome-proliferator-activated receptor-gamma coactivator-1
- Serine
- Proline
- Alanine
- Glycine
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Topics |
- Aged
- Alanine
(genetics)
- Diabetes Mellitus, Type 2
(complications, genetics)
- Diabetic Retinopathy
(genetics)
- Female
- Genetic Predisposition to Disease
- Genotype
- Glycine
(genetics)
- Humans
- Logistic Models
- Male
- Middle Aged
- PPAR gamma
(genetics)
- Polymorphism, Genetic
(genetics)
- Proline
(genetics)
- Serine
(genetics)
- Slovenia
- Transcription Factors
(genetics)
- White People
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