A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia.

Abstract

PURPOSE:

To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia.

MATERIALS AND METHODS:

Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment.

RESULTS:

HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance.

CONCLUSION:

SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes.

• Authors: Ned Sacktor, Richard L Skolasky, Thomas Ernst, Xiangling Mao, Ola Selnes, Martin G Pomper, Linda Chang, Kai Zhong, Dikoma C Shungu, Karen Marder, Dean Shibata, Giovanni Schifitto, Linda Bobo, Peter B Barker
• Journal: Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 21 Issue 4 Pg. 325-33 (Apr 2005) ISSN: 1053-1807 [Print] United States
• PMID: 15779034 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2005 Wiley-Liss, Inc.

Chemical References

• Inositol
• Creatinine

Topics

• AIDS Dementia Complex (diagnosis)
• Adult
• Brain Chemistry
• Creatinine (analysis)
• Female
• Humans
• Inositol (analysis)
• Magnetic Resonance Spectroscopy (methods)
• Male