Effect of 5-Campestenone (24-methylcholest-5-en-3-one) on Zucker diabetic fatty rats as a type 2 diabetes mellitus model.

Abstract

We examined the therapeutic effects of dietary exposure to 5-campestenone (24-methylcholest-5-en-3-one), an enone derivative of campesterol, in Zucker diabetic fatty (ZDF) rats, an animal model of type 2 diabetes mellitus. Dietary 0.6 % exposure to 5-campestenone caused marked reduction in hemoglobin A1c (HbA1c), plasma total cholesterol, triglycerides and non esterified fatty acid (NEFA). In particular, plasma triglyceride levels were reduced in the 0.6 % 5-campestenone-fed group to about 25 % of that in the control group. In the oral glucose tolerance test (OGTT) at three and seven weeks after the beginning of treatment, 5-campestenone limited the rise of blood glucose levels by oral administration of glucose dose-dependently. Amounts of adipose tissue in the retroperitoneum and periepididymal area as well as abdominal subcutaneous fat were significantly decreased in animals fed 0.6 % 5-campestenone. The blood leptin concentration on the final day of feeding was significantly in animals administered 5-campestenone. No obvious anomaly due to consumption of 5-campestenone was detected in necropsy or clinical observations.

• Authors: R Konno, Y Kaneko, K Suzuki, Y Matsui
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 37 Issue 2 Pg. 79-83 (Feb 2005) ISSN: 0018-5043 [Print] Germany
• PMID: 15778923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-campestenone
• Blood Glucose
• Cholestenones
• Leptin
• Lipids
• Hemoglobin A

Topics

• Administration, Oral
• Animals
• Blood Glucose (analysis)
• Cholestenones (administration & dosage)
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Diet
• Disease Models, Animal
• Glucose Tolerance Test
• Hemoglobin A (analysis)
• Leptin (blood)
• Lipids (blood)
• Rats
• Rats, Zucker