HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hyperbaric oxygen induces rapid protection against focal cerebral ischemia.

AbstractBACKGROUND AND PURPOSE:
The timing and mechanisms of protection by hyperbaric oxygen (HBO) in cerebral ischemia have only been partially elucidated. We monitored the early in vivo effects of HBO after 2 h transient focal ischemia using repetitive MRI.
METHODS:
Wistar rats underwent filament occlusion of the middle cerebral artery (MCAO). 40 min after MCAO, rats were placed in a HBO chamber and breathed either 100% O(2) at 3.0 atmospheres absolute (ata; n = 24) or at 1.0 ata (control; n = 24) for 1 h. Diffusion, perfusion and T2-weighted MR-images were obtained after 15 min and 3, 6 and 24 h of reperfusion. In 6 axial MR slices, volume of abnormal diffusion and T2w signals were measured in the ischemic hemisphere. Furthermore, hemispheric mean apparent diffusion coefficient- (ADC) and T2 values were calculated for statistical analysis.
RESULTS:
HBO significantly reduced volume of abnormal DWI signal beginning immediately after reperfusion (control: 92 +/- 28 mm(3); HBO: 64 +/- 17) and lesion size on T2w (control: 375 +/- 91 mm(3); HBO: 225 +/- 39) after 24 h. Correspondingly, mean ADC levels were lower and T2 values higher in the ischemic hemisphere in the control group. HBO reduced histological infarct size at 24 h.
CONCLUSION:
High-dose intraischemic HBO therapy has an immediate protective on the brain which is superior to normobaric oxygen.
AuthorsRoland Veltkamp, Dirk A Siebing, Sabine Heiland, Philip Schoenffeldt-Varas, Claudia Veltkamp, Markus Schwaninger, Stefan Schwab
JournalBrain research (Brain Res) Vol. 1037 Issue 1-2 Pg. 134-8 (Mar 10 2005) ISSN: 0006-8993 [Print] Netherlands
PMID15777761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Animals
  • Functional Laterality (physiology)
  • Hyperbaric Oxygenation
  • Infarction, Middle Cerebral Artery (pathology)
  • Ischemic Attack, Transient (pathology, prevention & control)
  • Magnetic Resonance Imaging
  • Male
  • Rats
  • Rats, Wistar

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: