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Hyperbaric oxygen induces rapid protection against focal cerebral ischemia.

AbstractBACKGROUND AND PURPOSE:
The timing and mechanisms of protection by hyperbaric oxygen (HBO) in cerebral ischemia have only been partially elucidated. We monitored the early in vivo effects of HBO after 2 h transient focal ischemia using repetitive MRI.
METHODS:
Wistar rats underwent filament occlusion of the middle cerebral artery (MCAO). 40 min after MCAO, rats were placed in a HBO chamber and breathed either 100% O(2) at 3.0 atmospheres absolute (ata; n = 24) or at 1.0 ata (control; n = 24) for 1 h. Diffusion, perfusion and T2-weighted MR-images were obtained after 15 min and 3, 6 and 24 h of reperfusion. In 6 axial MR slices, volume of abnormal diffusion and T2w signals were measured in the ischemic hemisphere. Furthermore, hemispheric mean apparent diffusion coefficient- (ADC) and T2 values were calculated for statistical analysis.
RESULTS:
HBO significantly reduced volume of abnormal DWI signal beginning immediately after reperfusion (control: 92 +/- 28 mm(3); HBO: 64 +/- 17) and lesion size on T2w (control: 375 +/- 91 mm(3); HBO: 225 +/- 39) after 24 h. Correspondingly, mean ADC levels were lower and T2 values higher in the ischemic hemisphere in the control group. HBO reduced histological infarct size at 24 h.
CONCLUSION:
High-dose intraischemic HBO therapy has an immediate protective on the brain which is superior to normobaric oxygen.
AuthorsRoland Veltkamp, Dirk A Siebing, Sabine Heiland, Philip Schoenffeldt-Varas, Claudia Veltkamp, Markus Schwaninger, Stefan Schwab
JournalBrain research (Brain Res) Vol. 1037 Issue 1-2 Pg. 134-8 (Mar 10 2005) ISSN: 0006-8993 [Print] Netherlands
PMID15777761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Animals
  • Functional Laterality (physiology)
  • Hyperbaric Oxygenation
  • Infarction, Middle Cerebral Artery (pathology)
  • Ischemic Attack, Transient (pathology, prevention & control)
  • Magnetic Resonance Imaging
  • Male
  • Rats
  • Rats, Wistar

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