Acute generalized lichen planus treated with weekly betamethasone 5-mg oral mini-pulse therapy.

A 54-year-old male presented with a sudden generalized eruption of itchy violaceous papules, annular plaques, superficial vesicles, and erosions involving his trunk, limbs, oral cavity, and genitalia. The biopsy showed features of lichen planus (LP). Direct and indirect immunofluorescence (IF) was negative. Systemic treatment with oral corticosteroids in the form of 10 tablets of betamethasone 0.5 mg in a single dose was given after breakfast on 2 consecutive days every week. Complete arrest of progression, control of itching, and flattening of lesions was achieved within 3 weeks allowing tapering of the dose of corticosteroid by 0.5 mg every 2 weeks over next 10 weeks. No side effects of corticosteroid therapy were noted and the patient is in remission.
AuthorsNawaf Al-Mutairi, Arun Joshi, Amr Zaki, Ashok Kumar Sharma, Osama Nour-Eldin
JournalJournal of drugs in dermatology : JDD (J Drugs Dermatol) 2005 Mar-Apr Vol. 4 Issue 2 Pg. 218-20 ISSN: 1545-9616 [Print] United States
PMID15776780 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Betamethasone
  • Acute Disease
  • Administration, Oral
  • Betamethasone (administration & dosage)
  • Humans
  • Lichen Planus (drug therapy)
  • Male
  • Middle Aged

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