CP-82,009, a potent polyether anticoccidial related to septamycin and produced by Actinomadura sp.

Abstract

A new polyether antibiotic CP-82,009 (C49H84O17) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53676). Following purification by column chromatography and crystallization, the structure of CP-82,009 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-82,009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Serpulina (Treponema) hyodysenteriae.

• Authors: J P Dirlam, A M Belton, J Bordner, W P Cullen, L H Huang, Y Kojima, H Maeda, S Nishiyama, J R Oscarson, A P Ricketts
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 45 Issue 3 Pg. 331-40 (Mar 1992) ISSN: 0021-8820 [Print] England
• PMID: 1577662 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Coccidiostats
• Ethers
• Pyrans
• CP 82009
• septamycin

Topics

• Actinomycetales (classification, metabolism)
• Animals
• Anti-Bacterial Agents (isolation & purification, pharmacology)
• Bacteria (drug effects)
• Chickens
• Coccidiostats (isolation & purification, pharmacology)
• Ethers (isolation & purification, pharmacology)
• Fermentation
• Molecular Conformation
• Pyrans (isolation & purification, pharmacology)
• X-Ray Diffraction