Abstract |
Infection with human T lymphotropic virus type II (HTLV-II) has been linked to an increased incidence of bacterial pneumonia. To determine whether HTLV-II infection is associated with impaired humoral immune responses, we immunized a cohort of HTLV-II-infected subjects and matched uninfected control subjects with 23-valent pneumococcal polysaccharide and tetanus toxoid vaccines. The pneumococcal polysaccharide vaccine elicited comparable and significant increases in concentrations of IgG against all 5 serotypes tested at 1 and 6 months after immunization in both groups. The avidity and opsonophagocytic functions of the anticapsular IgG were similar. The concentrations of tetanus toxoid-specific IgG also increased comparably and significantly over time in both groups. Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines.
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Authors | Gary A Jarvis, Edward N Janoff, Hui Cheng, Deborah Devita, Claudine Fasching, Charles E McCulloch, Edward L Murphy |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 191
Issue 8
Pg. 1239-44
(Apr 15 2005)
ISSN: 0022-1899 [Print] United States |
PMID | 15776369
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Immunoglobulin G
- Pneumococcal Vaccines
- Tetanus Toxoid
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Topics |
- Adult
- Aged
- Antibody Affinity
- Cohort Studies
- Female
- HTLV-II Infections
(immunology)
- Humans
- Immunization
- Immunoglobulin G
(immunology)
- Least-Squares Analysis
- Male
- Middle Aged
- Phagocytosis
- Pneumococcal Vaccines
(immunology)
- Streptococcus pneumoniae
(classification, immunology)
- Tetanus Toxoid
(immunology)
- Time Factors
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