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Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines.

Abstract
Infection with human T lymphotropic virus type II (HTLV-II) has been linked to an increased incidence of bacterial pneumonia. To determine whether HTLV-II infection is associated with impaired humoral immune responses, we immunized a cohort of HTLV-II-infected subjects and matched uninfected control subjects with 23-valent pneumococcal polysaccharide and tetanus toxoid vaccines. The pneumococcal polysaccharide vaccine elicited comparable and significant increases in concentrations of IgG against all 5 serotypes tested at 1 and 6 months after immunization in both groups. The avidity and opsonophagocytic functions of the anticapsular IgG were similar. The concentrations of tetanus toxoid-specific IgG also increased comparably and significantly over time in both groups. Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines.
AuthorsGary A Jarvis, Edward N Janoff, Hui Cheng, Deborah Devita, Claudine Fasching, Charles E McCulloch, Edward L Murphy
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 191 Issue 8 Pg. 1239-44 (Apr 15 2005) ISSN: 0022-1899 [Print] United States
PMID15776369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Immunoglobulin G
  • Pneumococcal Vaccines
  • Tetanus Toxoid
Topics
  • Adult
  • Aged
  • Antibody Affinity
  • Cohort Studies
  • Female
  • HTLV-II Infections (immunology)
  • Humans
  • Immunization
  • Immunoglobulin G (immunology)
  • Least-Squares Analysis
  • Male
  • Middle Aged
  • Phagocytosis
  • Pneumococcal Vaccines (immunology)
  • Streptococcus pneumoniae (classification, immunology)
  • Tetanus Toxoid (immunology)
  • Time Factors

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