HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine.

Abstract
The pathophysiology underlying the involuntary tics of Gilles de la Tourette syndrome (GTS) remains unknown. Here we used transcranial magnetic stimulation (TMS) to examine the excitability of two different inhibitory systems in the human motor cortex: short interval intracortical inhibition (SICI) and short interval afferent inhibition (SAI) in 10 healthy non-smoking controls and eight untreated non-smoking patients with GTS. Compared with the healthy control group, both SICI (measured at a range of conditioning intensities) and SAI were reduced in patients. This is consistent with the suggestion that reduced excitability of cortical inhibition is one factor that contributes to the difficulty that patients have in suppressing involuntary tics. In addition, the reduced SAI indicates that impaired intracortical inhibition may not be limited to the motor cortex but also involves circuits linking sensory input and motor output. A single dose of nicotine reduced tic severity as assessed by blind video scoring in the majority of patients. In addition, it abolished the difference between patients and controls in SICI and SAI. There was no effect of nicotine, and no difference between controls and patients in measures of motor or SICI threshold. This indicates that cholinergic input can modulate the efficiency of SICI and SAI differently in GTS and healthy controls.
AuthorsM Orth, B Amann, M M Robertson, J C Rothwell
JournalBrain : a journal of neurology (Brain) Vol. 128 Issue Pt 6 Pg. 1292-300 (Jun 2005) ISSN: 1460-2156 [Electronic] England
PMID15774505 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Nicotinic Agonists
  • Nicotine
Topics
  • Adult
  • Electromyography
  • Evoked Potentials, Motor (drug effects)
  • Female
  • Humans
  • Magnetics
  • Male
  • Middle Aged
  • Motor Cortex (drug effects, physiopathology)
  • Neural Inhibition (drug effects)
  • Neurons, Afferent
  • Nicotine (pharmacology, therapeutic use)
  • Nicotinic Agonists (pharmacology, therapeutic use)
  • Severity of Illness Index
  • Tics (drug therapy, physiopathology)
  • Tourette Syndrome (drug therapy, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: