Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour.

Abstract

The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour. Human and bovine WE-14 are structurally identical, while rat, mouse and porcine analogues exhibit 93% homology. WE-14 is flanked by paired basic residues (KR) in all known chromogranin A sequences.

• Authors: W J Curry, C Shaw, C F Johnston, L Thim, K D Buchanan
• Journal: FEBS letters (FEBS Lett) Vol. 301 Issue 3 Pg. 319-21 (Apr 27 1992) ISSN: 0014-5793 [Print] England
• PMID: 1577173 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CHGA protein, human
• Chromogranin A
• Chromogranins
• Neoplasm Proteins
• chromogranin A, mouse
• chromogranin A, rat
• chromogranin A-derived peptide, WE-14

Topics

• Amino Acid Sequence
• Carcinoid Tumor (metabolism, pathology)
• Chromatography, Gel
• Chromatography, High Pressure Liquid
• Chromogranin A
• Chromogranins (metabolism)
• Humans
• Intestinal Neoplasms (metabolism, pathology)
• Liver Neoplasms (metabolism, secondary)
• Male
• Middle Aged
• Molecular Sequence Data
• Neoplasm Proteins (genetics, isolation & purification)
• Protein Processing, Post-Translational
• Radioimmunoassay