Efficacy of etidronate and sequential monofluorophosphate in severe postmenopausal osteoporosis: a pilot study.

Abstract

In a three-year pilot study on 52 women with severe postmenopausal osteoporosis, treatment with etidronate followed by calcium and vitamin D (ECaD) was compared to etidronate followed by monofluorophosphate, calcium and vitamin D (EFCaD). BMD in lumbar spine, total hip and femoral neck increased significantly more with EFCaD than with ECaD. Pain-mobility score decreased significantly more with EFCaD than with ECaD (p=0.006). New vertebral fractures occurred in three patients under EFCaD (12%) and in nine under ECaD (35%), (p=0.048). Three patients under EFCaD (12%) and 15 under ECaD (58%) did not respond to therapy (p of difference=0.001). Mild or moderate adverse reactions were reported by 25 patients, with no significant difference between the two groups. The pilot study suggests that etidronate, sequentially followed by monofluorophosphate, could be a safe, effective and relatively inexpensive therapy in severe postmenopausal osteoporosis.

• Authors: J D Ringe, A Dorst, H Faber, C Kipshoven, L C Rovati, I Setnikar
• Journal: Rheumatology international (Rheumatol Int) Vol. 25 Issue 4 Pg. 296-300 (May 2005) ISSN: 0172-8172 [Print] Germany
• PMID: 15770482 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Phosphates
• Vitamin D
• fluorophosphate
• Etidronic Acid
• Fluorides
• Calcium

Topics

• Absorptiometry, Photon
• Aged
• Bone Density (drug effects)
• Bone and Bones (diagnostic imaging, metabolism)
• Calcaneus (diagnostic imaging, drug effects, physiopathology)
• Calcium (administration & dosage)
• Dietary Supplements
• Drug Therapy, Combination
• Etidronic Acid (therapeutic use)
• Female
• Fluorides (therapeutic use)
• Fractures, Spontaneous (prevention & control)
• Humans
• Osteoporosis, Postmenopausal (metabolism, physiopathology, therapy)
• Pain (physiopathology, prevention & control)
• Phosphates (therapeutic use)
• Pilot Projects
• Range of Motion, Articular (drug effects)
• Spinal Fractures (diagnostic imaging, prevention & control)
• Treatment Outcome
• Ultrasonography
• Vitamin D (administration & dosage)