Abstract | BACKGROUND: The therapeutic efficacy of bezafibrate, a hypolipidemic drug, has been shown in patients with primary biliary cirrhosis (PBC) in some pilot studies; however, little is known regarding the mechanism of action of bezafibrate in PBC. This study was conducted to evaluate the therapeutic efficacy, as well as to gain insight about the possible mechanism of action, of bezafibrate in PBC. METHODS: Sixteen patients with PBC were administered with bezafibrate (400 mg/day) either with (n = 10) or without ursodeoxycholic acid (UDCA; n = 6). The peripheral blood of these patients was collected before and at different times after therapy commencement, and antigen-presenting dendritic cells (DCs) were then cultured. The DCs were enriched and cultured with Staphylococcus aureus Cowan strain-1 for 48 h to evaluate their capacity to produce nitrite. RESULTS: CONCLUSIONS: This study reconfirms the therapeutic efficacy of bezafibrate in patients with PBC, including those with UDCA-resistant PBC. Downregulation of nitrite production by DCs may have some relationship with the therapeutic efficacy of bezafibrate; however, further study will be needed to clarify whether or not the antiinflammatory activity of bezafibrate is mediated through nitrite production.
|
Authors | Sk Md Fazle Akbar, Shinya Furukawa, Seiji Nakanishi, Masanori Abe, Norio Horiike, Morikazu Onji |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 40
Issue 2
Pg. 157-63
(Feb 2005)
ISSN: 0944-1174 [Print] Japan |
PMID | 15770399
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Hypolipidemic Agents
- Nitrites
- Bezafibrate
|
Topics |
- Adult
- Bezafibrate
(pharmacology, therapeutic use)
- Female
- Humans
- Hypolipidemic Agents
(pharmacology, therapeutic use)
- Liver Cirrhosis, Biliary
(drug therapy, physiopathology)
- Liver Function Tests
- Middle Aged
- Nitrites
(metabolism)
|