| Abstract | Receptors for products of non-enzymatic glycosylation have been identified previously on activated human monocytes. In this study we have found that medium conditioned by activated human monocytes following stimulation with AGE-BSA elicited an almost 3-fold greater chemotactic response from other activated monocytes than conditioned medium obtained following stimulation with control BSA (44 +/- 13 and 16 +/- 4.6, respectively; n = 9, P less than 0.05). The response elicited from AGE-BSA alone was not statistically significant. It appears that stimulation of the cells via the AGE-receptor results in the secretion of increased levels of a chemotactic substance(s) for monocytes/macrophages. This mechanism may help to explain the pathogenesis of atherosclerosis in diabetes, as monocyte accumulation within the vessel wall is an important step in fatty streak development. |
| Authors | M Z Gilcrease, R L Hoover
(Affiliation: Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232.)
|
| Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 16
Issue 1
Pg. 7-11
(Apr 1992)
ISSN: 0168-8227 NETHERLANDS |
| PMID | 1576934
(Publication Type: In Vitro, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Chemotactic Factors
- Endotoxins
- Serum Albumin
- Serum Albumin, Bovine
- glycosylated serum albumin
|
| Topics |
- Chemotactic Factors
(blood, secretion)
- Chemotaxis, Leukocyte
- Endotoxins
(pharmacology)
- Glycosylation
- Humans
- Monocytes
(drug effects, physiology)
- Serum Albumin
(pharmacology)
- Serum Albumin, Bovine
|
