Transepithelial phototherapeutic keratectomy/photorefractive keratectomy with adjunctive mitomycin-C for complicated LASIK flaps.

Abstract

PURPOSE:

To evaluate the efficacy of transepithelial phototherapeutic keratectomy/photorefractive keratectomy (PTK/PRK) with prophylactic mitomycin-C for the treatment of refractive errors and maintenance of corneal clarity following flap complications in laser in situ keratomileusis (LASIK).

SETTING:

Outpatient tertiary care center, Chicago, Illinois, USA.

METHODS:

Ten eyes of 10 patients with LASIK flap complications had transepithelial PTK/PRK for correction of ametropia. Mitomycin-C 0.02% was applied to the stroma for 2 minutes following laser ablation. Postoperative uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refractions, and slitlamp examinations were obtained.

RESULTS:

Preoperatively, the mean UCVA was 20/400 (range 20/40 to counting fingers), the mean BSCVA was 20/28.5, and the spherical equivalent refractive errors ranged from +4.00 to -10.75 diopters (D). After the procedure, the mean UCVA was 20/28, the mean BSCVA was 20/21, and the spherical equivalent refractive errors ranged from +0.37 to -1.00 D. The mean follow-up ranged from 8 to 28 months. No patient experienced delayed reepithelialization, haze, or other signs of toxicity.

CONCLUSION:

Mitomycin-C can be a useful adjunctive therapy for the prevention of haze when applying surface excimer laser therapy to a cornea following LASIK flap complications.

• Authors: Laura T Muller, Eugenio M Candal, Randy J Epstein, Richard F Dennis, Parag A Majmudar
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 31 Issue 2 Pg. 291-6 (Feb 2005) ISSN: 0886-3350 [Print] United States
• PMID: 15767148 (Publication Type: Journal Article)

Chemical References

• Alkylating Agents
• Mitomycin

Topics

• Adult
• Alkylating Agents (therapeutic use)
• Chemotherapy, Adjuvant
• Corneal Stroma (drug effects, surgery)
• Epithelial Cells
• Female
• Humans
• Intraoperative Complications
• Keratomileusis, Laser In Situ
• Lasers, Excimer
• Male
• Middle Aged
• Mitomycin (therapeutic use)
• Photorefractive Keratectomy (methods)
• Surgical Flaps
• Visual Acuity