Labelling of manganese-based magnetic resonance imaging (MRI) contrast agents with the positron emitter 51Mn, as exemplified by manganese-tetraphenyl-porphin-sulfonate (MnTPPS4).

Abstract

The potential tumor seeking MRI contrast agent MnTPPS(4) was labelled with the positron emitting nuclide (51)Mn in no-carrier-added (n.c.a.) form. The complex formation kinetics were investigated and the apparent rate constants were determined under pseudo-first-order conditions. The derived bimolecular rate constants gave the Arrhenius parameters E(A)=84 kJ mol(-1) and A=2 x 10(12)s(-1)M(-1). Optimum labelling conditions were derived (radiochemical yields >99% possible, effective yields about 32%). Separation and purification of n.c.a. (51)MnTPPS(4) were performed for potential human use. All impurities were <1%.

• Authors: A T J Klein, F Rösch, H H Coenen, S M Qaim
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 62 Issue 5 Pg. 711-20 (May 2005) ISSN: 0969-8043 [Print] England
• PMID: 15763477 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Porphyrins
• tetraphenylporphine sulfonate
• Manganese

Topics

• Contrast Media (chemistry)
• Humans
• Kinetics
• Magnetic Resonance Imaging
• Manganese (chemistry)
• Neoplasms (diagnosis)
• Porphyrins (chemistry, isolation & purification)