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Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study.

Abstract
Pruritus is a common and disabling symptom for patients undergoing hemodialysis. Many topical and systemic treatments have been used for uremic pruritus, mostly in anecdotal reports. A recent case series demonstrated that topical tacrolimus ointment 0.03% had a significant antipruritic effect for patients with uremia. In an attempt to confirm these findings, we conducted a randomized, double-blind, vehicle-controlled study to assess the efficacy of tacrolimus ointment 0.1% for the treatment of hemodialysis-related pruritus. The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus.
AuthorsMaria I Duque, Gil Yosipovitch, Alan B Fleischer Jr, Joy Willard, Barry I Freedman
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 52 Issue 3 Pt 1 Pg. 519-21 (Mar 2005) ISSN: 1097-6787 [Electronic] United States
PMID15761435 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Immunosuppressive Agents
  • Ointments
  • Tacrolimus
Topics
  • Administration, Topical
  • Aged
  • Double-Blind Method
  • Humans
  • Immunosuppressive Agents (administration & dosage, therapeutic use)
  • Middle Aged
  • Ointments
  • Pruritus (drug therapy, etiology)
  • Renal Dialysis (adverse effects)
  • Tacrolimus (administration & dosage, therapeutic use)
  • Uremia (complications)

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