Abstract |
1. Single doses (500 and 1000 mg) of both buffered aspirin and aspirin tablets were compared with placebo in a randomised double-blind trial of parallel design in patients with postoperative pain after third molar surgery. 2. Only buffered aspirin 500 mg provided significant pain relief (P = 0.016) during the 5 h investigation period. 3. A significant correlation (P = 0.004) was observed between overall pain scores after the various aspirin treatments and aspirin esterase activity. 4. Buffered aspirin preparations afforded a slight advantage over aspirin tablets in the control of postoperative pain after third molar surgery. However, the duration of analgesia was short (approximately 2 h). 5. Aspirin esterase activity appears to be an important determinant of the drug's efficacy in postoperative dental pain.
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Authors | R A Seymour, M Weldon, P Kelly, E Nicholson, J E Hawkesford |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 33
Issue 4
Pg. 395-9
(Apr 1992)
ISSN: 0306-5251 [Print] England |
PMID | 1576068
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aspirin
(administration & dosage, therapeutic use)
- Buffers
- Female
- Humans
- Male
- Molar, Third
(surgery)
- Pain, Postoperative
(drug therapy)
- Tablets
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