The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers.

Abstract	Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 x 100 microm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.
Authors	D Fraser Steele, Paul M Young, Robert Price, Timothy Smith, Stephen Edge, David Lewis
Journal	The AAPS journal (AAPS J) Vol. 6 Issue 4 Pg. e32 (Oct 29 2004) ISSN: 1550-7416 [Electronic] United States
PMID	15760097 (Publication Type: Evaluation Study, Journal Article)
Chemical References	Aerosols Anti-Asthmatic Agents Beclomethasone Albuterol
Topics	Aerosols (analysis) Albuterol (administration & dosage, analysis) Anti-Asthmatic Agents (administration & dosage, analysis) Beclomethasone (administration & dosage, analysis) Metered Dose Inhalers Microscopy, Electron, Scanning Pressure Spectrum Analysis, Raman (methods)

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