Abstract | OBJECTIVE: DESIGN: A comparative study. SETTING: An inpatient rehabilitation unit in Korea. SUBJECTS: We examined eight adult patients who had severe TBI approximately five months before. Fourteen normal controls were employed for comparison. MAIN MEASURES: Image-guided localized in vivo 1H-MRS was performed in the parietal white matter and occipital grey matter regions in brain in which no definite abnormalities in MR imaging were found at the time of 1H-MRS examination. We evaluated functional status for all patients with the Functional Independence Measure (FIM) on the same day as the 1H-MRS examination and compared the results. RESULTS: CONCLUSIONS: A spectral feature of the decreased [ N-acetyl aspartate/ creatine] and increased [ choline/ creatine] and [myo- inositol/ creatine] ratios in parietal white matter may be a marker for diffuse axonal injury in patients with TBI and has a significant correlation with the functional status of the patients. Localized 1H-MRS has the potential to be used for detecting diffuse axonal injury in vivo in TBI patients, which can be used to guide evaluation of the functional status of TBI patients receiving rehabilitation.
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Authors | Se Jin Yoon, Jung Hee Lee, Sang Tae Kim, Min Ho Chun |
Journal | Clinical rehabilitation
(Clin Rehabil)
Vol. 19
Issue 2
Pg. 209-15
(Mar 2005)
ISSN: 0269-2155 [Print] England |
PMID | 15759537
(Publication Type: Journal Article)
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Topics |
- Activities of Daily Living
- Adult
- Brain Injuries
(classification, pathology)
- Evaluation Studies as Topic
- Female
- Humans
- Injury Severity Score
- Korea
- Male
- Nuclear Magnetic Resonance, Biomolecular
- Rehabilitation Centers
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