Inhibitory effects of (1E,3E,5E,7E)-5-hydroxy-4-(8-phenyl-1,3,5,7- octatetraenyl)-2(5H)-furanone on proliferation of human malignant tumor cells.

Abstract

A butenolide compound (1E,3E,5E,7E)-5-hydroxy-4-(8-phenyl-1,3,5,7- octatetraenyl)-2(5H)-furanone (KNK-41), was shown to have strong anti-tumor activity. KNK-41 inhibited the proliferation of various kinds of human malignant tumor cells, such as HeLa (cervical carcinoma), HGC-27 (gastric cancer), PANC-1 (pancreatic cancer) and GOTO (neuroblastoma). Flow cytometric analysis indicated that KNK-41 caused an arrest in G0/G1 phase of the cell cycle. However, it scarcely affected DNA synthesis and the level of c-myc mRNA. These results suggest that the growth-inhibitory effect of KNK-41 is the result of G0/G1 arrest and not of the suppression of DNA synthesis and/or c-myc expression.

• Authors: Y Satomi, H Nishino, A Iwashima, M Torihara, Y Tamai, M Ito
• Journal: Anti-cancer drug design (Anticancer Drug Des) Vol. 7 Issue 2 Pg. 169-79 (Apr 1992) ISSN: 0266-9536 [Print] United States
• PMID: 1575890 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• DNA, Neoplasm
• Furans
• Neoplasm Proteins
• RNA, Messenger
• 5-hydroxy-4-(8-phenyl-1,3,5,7-octatetraenyl)-2(5H)-furanone
• peridinin
• Carotenoids
• butenolide
• 4-Butyrolactone
• Thymidine

Topics

• 4-Butyrolactone (analogs & derivatives)
• Antineoplastic Agents (pharmacology)
• Blotting, Northern
• Carotenoids (pharmacology)
• Cell Division (drug effects)
• DNA, Neoplasm (drug effects)
• Flow Cytometry
• Furans (pharmacology)
• Genes, myc
• HeLa Cells
• Humans
• Neoplasm Proteins (biosynthesis)
• Neuroblastoma (pathology)
• Pancreatic Neoplasms (pathology)
• RNA, Messenger (drug effects)
• Stomach Neoplasms (pathology)
• Thymidine (metabolism)
• Tumor Cells, Cultured (drug effects, pathology)