Abstract |
Immunohistochemical analysis employing a monoclonal antibody nm23-H1 (the antibody against nm-23 protein) was performed on archival material, consisting of 12 cases of follicular thyroid carcinoma ( FTC), 57 cases of follicular thyroid adenoma (FTA) and 17 cases of nodular goiter (NG). Both cytoplasmic and nuclear immunoreactions for nm-23H1 were observed in cells of FTCs, FTAs and NGs. In oxyphilic adenomas cytoplasmic staining was observed. Eleven (91.7%) cases of FTC, 55 (98.2%) cases of FTA and 14 (82.4%) cases of NG were found to be positive for nm23-H1 protein. There were no statistically significant differences in the mean percentage values of immunopositive cells between carcinomas and adenomas. A significant increase in the number of cases with high percentage (more than 50) of positive cells was found in both carcinomas (FTCs) and adenomas (FTAs)--mainly microfollicular ones, in comparison with nodular goiter. It can be concluded that highly positive immunoreaction for the nm23-H1 protein in the cells of carcinomas (FTCs) and microfollicular adenomas indicates for a high proliferation rate of these tumors.
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Authors | Tomasz Ferenc, Andrzej Lewiński, Dariusz Lange, Hanna Niewiadomska, Jacek Sygut, Stanisław Sporny, Jan Włoch, Elzbieta Sałacińska-Los, Andrzej Kulig, Barbara Jarzab |
Journal | Polish journal of pathology : official journal of the Polish Society of Pathologists
(Pol J Pathol)
Vol. 55
Issue 4
Pg. 149-53
( 2004)
ISSN: 1233-9687 [Print] Poland |
PMID | 15757202
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- NM23 Nucleoside Diphosphate Kinases
- NME1 protein, human
- Nucleoside-Diphosphate Kinase
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Topics |
- Adenocarcinoma, Follicular
(metabolism, pathology)
- Adenoma
(metabolism, pathology)
- Biomarkers, Tumor
(analysis)
- Genes, Tumor Suppressor
- Goiter, Nodular
(metabolism, pathology)
- Humans
- Immunohistochemistry
- NM23 Nucleoside Diphosphate Kinases
- Nucleoside-Diphosphate Kinase
(biosynthesis)
- Retrospective Studies
- Thyroid Neoplasms
(metabolism, pathology)
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