Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides.

Abstract

We have investigated the lipid polylysine core peptide (LCP) system as a self-adjuvanting group A streptococcal (GAS) vaccine delivery approach. LCP constructs were synthesised incorporating peptides from the M protein conserved carboxy terminal C-repeat region, the amino terminal type-specific region and from both of these regions. Immunisation with the constructs without adjuvant led to the induction of peptide-specific serum IgG antibody responses, heterologous opsonic antibodies, and complete protection from GAS infection. These data indicate that protective immunity to GAS infection can be evoked using the self-adjuvanting LCP system, and point to the potential application of this system in human mucosal GAS vaccine development.

• Authors: Colleen Olive, K Hsien, A Horváth, T Clair, P Yarwood, I Toth, M F Good
• Journal: Vaccine (Vaccine) Vol. 23 Issue 17-18 Pg. 2298-303 (Mar 18 2005) ISSN: 0264-410X [Print] Netherlands
• PMID: 15755615 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Bacterial Outer Membrane Proteins
• Carrier Proteins
• Immunoglobulin G
• Immunologic Factors
• Lipids
• Opsonin Proteins
• Streptococcal Vaccines
• Vaccines, Subunit
• streptococcal M protein

Topics

• Amino Acid Sequence
• Animals
• Antibodies, Bacterial (blood)
• Antigens, Bacterial (chemistry, genetics, immunology)
• Bacterial Outer Membrane Proteins (chemistry, genetics, immunology)
• Carrier Proteins (chemistry, genetics, immunology)
• Female
• Immunoglobulin G (blood)
• Immunologic Factors (chemistry, immunology, pharmacology)
• Lipids (chemistry, immunology)
• Mice
• Molecular Sequence Data
• Opsonin Proteins (blood)
• Streptococcal Infections (immunology, prevention & control)
• Streptococcal Vaccines (genetics, immunology, pharmacology)
• Streptococcus pyogenes (genetics, immunology)
• Vaccines, Subunit (genetics, immunology, pharmacology)