A 68-year-old man underwent subtotal
esophagectomy with two fields
lymphadenectomy and postoperative
chemotherapy so called low dose FP
therapy for advanced
esophageal cancer (Stage IIIa, pT 3, pN 1, M 0) in October 1999. As he was diagnosed with a recurrence of
esophageal cancer as metastatic lymph node
tumors which were placed in the right anterocervical and supraclavicular region in March 2001, he underwent enucleation of metastatic lymph node
tumors and postoperative chemoradiation
therapy, so-called low-dose FP-R
therapy. Recently, since other metastatic lymph node
tumors in the neck appeared again in August 2001, he underwent radical neck
lymph node dissection and postoperative chemoradiation treatment, so-called FAP-R
therapy. In October 2003, a chest CT showed multiple lung
tumors. He was diagnosed with multiple metastatic lung
tumors originating from
esophageal cancer. Then, two courses of a combined
chemotherapy consisting of
TS-1 and CDDP were administered at an interval of one month. We judged the effect of this
chemotherapy to be a partial response (PR), because the largest metastatic lung
tumor 18 mm in diameter showed a reduction rate of 81.9%, and other
tumors had almost disappeared in the chest CT after the combined
therapy. No severe adverse effects of more than grade 3 were observed during this combined
therapy. This combined
chemotherapy consisting of
TS-1 and CDDP may prove effective for treating recurrent cases of
esophageal cancer.