Ocular manifestations in patients with microscopic polyangiitis.

Abstract

PURPOSE:

To describe ocular manifestations in patients with microscopic polyangiitis.

METHODS:

Two patients with microscopic polyangiitis complained of ocular symptoms and underwent ophthalmologic examinations.

RESULTS:

An 83-year-old woman (Case 1) was diagnosed with microscopic polyangiitis, according to the general clinical findings and the presence of perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA). She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. The patient was treated with oral prednisolone and subconjunctival betamethasone. The hypopyon iridocyclitis and retinal cotton-wool spots responded. A 79-year-old man (Case 2) had bilateral scleritis. The diagnosis of microscopic polyangiitis was made based on general clinical findings and the presence of P-ANCA. Scleritis was reduced after corticosteroid treatment.

CONCLUSIONS:

Ophthalmologists should be aware that hypopyon iridocyclitis, cotton-wool spot, and scleritis could occur in patients with microscopic polyangiitis.

• Authors: M Mihara, S Hayasaka, K Watanabe, K Kitagawa, Y Hayasaka
• Journal: European journal of ophthalmology (Eur J Ophthalmol) 2005 Jan-Feb Vol. 15 Issue 1 Pg. 138-42 ISSN: 1120-6721 [Print] United States
• PMID: 15751255 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Glucocorticoids
• Betamethasone
• Prednisolone

Topics

• Aged
• Aged, 80 and over
• Anterior Eye Segment (drug effects, pathology)
• Antibodies, Antineutrophil Cytoplasmic (analysis)
• Betamethasone (therapeutic use)
• Drug Therapy, Combination
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Iridocyclitis (diagnosis, drug therapy, etiology)
• Male
• Polyarteritis Nodosa (complications, diagnosis, drug therapy)
• Prednisolone (therapeutic use)
• Retinal Diseases (diagnosis, drug therapy, etiology)
• Scleritis (diagnosis, drug therapy, etiology)
• Suppuration