Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.

Abstract

The inhibitory effects of dietary feeding of citrus nobiletin on azoxymethane (AOM)-induced rat colon carcinogenesis using a long-term bioassay were investigated. Five-week old male F344 rats were initiated with two weekly subcutaneous injections of AOM (20 mg/kg bw) to induce colonic tumors. They were also given the diets containing 0.01% or 0.05% nobiletin for 34 weeks, starting one week after the last dosing of AOM. At the end of the study, the incidence of colonic adenocarcinoma were 67% in the AOM alone group, 55% in the AOM-->0.01% nobiletin group, 35% (p<0.05) in the AOM-->0.05% nobiletin group. Also, nobiletin feeding reduced the cell-proliferation activity, increased the apoptotic index, and decreased the prostaglandin E2 content in colonic adenocarcinoma and/or colonic mucosa. These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis.

• Authors: Rikako Suzuki, Hiroyuki Kohno, Akira Murakami, Koichi Koshimizu, Hajime Ohigashi, Masamichi Yano, Harukuni Tokuda, Hoyoku Nishino, Takuji Tanaka
• Journal: BioFactors (Oxford, England) (Biofactors) Vol. 22 Issue 1-4 Pg. 111-4 ( 2004) ISSN: 0951-6433 [Print] Netherlands
• PMID: 15751122 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Flavones
• Polyamines
• Proliferating Cell Nuclear Antigen
• nobiletin
• Dinoprostone
• Azoxymethane

Topics

• Animals
• Anticarcinogenic Agents (pharmacology)
• Apoptosis (drug effects)
• Azoxymethane
• Citrus
• Colonic Neoplasms (chemically induced, prevention & control)
• Dinoprostone (metabolism)
• Flavones (pharmacology)
• Intestinal Mucosa (drug effects, metabolism, pathology)
• Male
• Phytotherapy
• Polyamines (metabolism)
• Proliferating Cell Nuclear Antigen (analysis)
• Rats
• Rats, Inbred F344