Abstract | OBJECTIVE: Alternative medical practices are common in the treatment of vertigo. This study compared the effects of Ginkgo biloba treatment with the homeopathic remedy Vertigoheel (Biologische Heilmittel Heel GmbH, Baden-Baden, Germany). DESIGN: Randomized, double-blinded, parallel group study. SUBJECTS: INTERVENTIONS: Patients were randomly allocated to receive treatment with either Vertigoheel (n = 87) or G. biloba (n = 83). OUTCOME MEASURES: The results were analyzed for the non-inferiority of Vertigoheel to G. biloba on the combined endpoint of changes from baseline to week 6 in dizziness score (assessed by questionnaire), frequency, duration, and intensity of vertigo episodes (recorded in patient diaries). RESULTS: Both treatments improved vertigo status. From a baseline mean value of 26.1 +/- 5.2 (on a 50-point scale) in the Vertigoheel group, the dizziness questionnaire score improved by -10.6 +/- 10.0, and by -10.7 +/- 9.0 from 25.8 - 4.7 in the G. biloba group. Statistical analysis of this endpoint showed that Vertigoheel was not inferior to G. biloba. The 95% confidence interval for the difference between treatment did not reach the inferiority threshold of 0.36 at any of the time points tested. The results were supported by the results of a line walking test, Unterberger's stepping test, and patient and physician global assessments of therapeutic effect. Both treatments were well tolerated. CONCLUSIONS:
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Authors | Wolfgang Issing, Peter Klein, Michael Weiser |
Journal | Journal of alternative and complementary medicine (New York, N.Y.)
(J Altern Complement Med)
Vol. 11
Issue 1
Pg. 155-60
(Feb 2005)
ISSN: 1075-5535 [Print] United States |
PMID | 15750375
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Minerals
- Plant Extracts
- Vasodilator Agents
- Vertigoheel
- Picrotoxin
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Topics |
- Aged
- Aged, 80 and over
- Arteriosclerosis
(complications)
- Confidence Intervals
- Dizziness
(drug therapy)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Combinations
- Female
- Ginkgo biloba
- Humans
- Male
- Middle Aged
- Minerals
(therapeutic use)
- Phytotherapy
- Picrotoxin
(therapeutic use)
- Plant Extracts
(therapeutic use)
- Time Factors
- Treatment Outcome
- Vasodilator Agents
(therapeutic use)
- Vertigo
(drug therapy, etiology)
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