QF-PCR examination of parental and meiotic origin of trisomy 21 in Central and Eastern Europe.

Abstract

Study of parental/meiotic origin of free trisomy 21 in nuclear families from Russia (70 cases), Ukraine (32 cases), and 22 from Germany revealed maternal nondisjunction in 77.3% (Germany), 93.8% (Ukraine), and 91.4% (Russia), paternal origin in 13.6%, 6.2%, and 8.6%, respectively. Maternal meiosis I errors were found in 84.4% (Ukraine), 77.1% (Russia), paternal origin in 3.1% (Ukraine), 2.9% (Russia). Maternal meiosis II errors occurred in 9.4% and 14.3% and paternal in 3.1% and 5.7% in Ukraine and Russia, respectively. No significant differences were found in maternal/paternal origin among Ukraine, Russia, Germany, and published data from other European regions.

• Authors: Marina Machatkova, Martina Brouckova, Milada Matejckova, Alice Krebsova, Karl Sperling, Svetlana Vorsanova, Sergei Kutsev, Tatiana Zerova, Svetlana Arbuzova, Roman Krejci, Michael Petersen, Milan Macek Sr
• Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (J Histochem Cytochem) Vol. 53 Issue 3 Pg. 371-3 (Mar 2005) ISSN: 0022-1554 [Print] United States
• PMID: 15750023 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Down Syndrome (epidemiology, genetics)
• Female
• Fluorescence
• Genomic Imprinting
• Germany (epidemiology)
• Humans
• Male
• Meiosis
• Nondisjunction, Genetic
• Parents
• Polymerase Chain Reaction
• Russia (epidemiology)
• Ukraine (epidemiology)